Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 8/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | TSSK3 | Q96PN8 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2184585 | 0.85 | HSP90AA1 (0.44) | CHEK2SYKLRRK2TSSK3 | |
| SCHEMBL12411763 | 0.84 | JAK2 (0.41) | CHEK2SYKLRRK2TSSK3 | |
| SCHEMBL12411776 | 0.84 | CHEK2 (0.37) | AMY1ACHEK2SYKLRRK2TSSK3 | |
| SCHEMBL2185941 | 0.82 | CHEK2 (0.42) | AMY1ACHEK2F7F2F10 | |
| SCHEMBL2182351 | 0.81 | CHEK2 (0.46) | CHEK2F7F2F10PLG | |
| SCHEMBL2182007 | 0.81 | CHEK2 (0.41) | AMY1ACHEK2F7METAP2METAP1 | |
| SCHEMBL13658326 | 0.78 | HSP90AA1 (0.48) | — | |
| SCHEMBL2180286 | 0.78 | AMY1A (0.40) | AMY1ACHEK2F2F10PLG | |
| SCHEMBL2180934 | 0.77 | CHEK2 (0.37) | AMY1ACHEK2F7HDAC6 | |
| SCHEMBL2181385 | 0.77 | HSP90AA1 (0.42) | AMY1ACHEK2F7KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009122034-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | WO | disclosed |