Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1317912 | 0.93 | MAPT (0.53) | MAPTNR1H4TDP1HTTMEN1 | |
| SCHEMBL1320740 | 0.83 | KMT2A (0.53) | MAPTNR1H4TDP1HTTMEN1 | |
| SCHEMBL12119362 | 0.81 | GAA (0.45) | MAPTTDP1GPR27ALDH1A1SMN1; SMN2 | |
| SCHEMBL13658789 | 0.80 | CHEK2 (0.45) | GPR27ALDH1A1SMN1; SMN2GAAPGR | |
| SCHEMBL12115916 | 0.78 | GPR27 (0.70) | MAPTTDP1MEN1KMT2AGPR27 | |
| SCHEMBL1110300 | 0.77 | POLB (0.48) | HTTGPR27ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL1320525 | 0.76 | KCNA5 (0.52) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL1110224 | 0.75 | AKR1C3 (0.60) | MEN1KMT2AGPR27ALDH1A1SMN1; SMN2 | |
| SCHEMBL11902028 | 0.74 | NR1H4 (0.79) | NR1H4ALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL12115929 | 0.74 | CPT1A (0.50) | GPR27ALDH1A1SMN1; SMN2GAAPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127723-A1 | NEW ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-22 | — | — | WO | disclosed |