GPR27 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Thioglycolic Acid (SCHEMBL491985)	0.60	11/20
SCHEMBL490518	0.60	11/20
SCHEMBL491567	0.47	11/20
Benzene (SCHEMBL490520)	0.60	9/20
SCHEMBL491880	0.55	9/20
SCHEMBL972679	0.55	9/20
SCHEMBL491711	0.60	8/20
SCHEMBL492283	0.57	8/20
SCHEMBL492270	0.56	8/20
SCHEMBL492299	0.56	8/20
SCHEMBL1380541	0.55	8/20
SCHEMBL492067	0.53	8/20
SCHEMBL492482	0.53	8/20
SCHEMBL491984	0.53	8/20
SCHEMBL1320934	0.52	8/20
SCHEMBL491895	0.50	8/20
SCHEMBL491998	0.46	8/20
SCHEMBL492118	0.60	7/20
SCHEMBL491625	0.60	7/20
SCHEMBL1138720	0.59	7/20

Clinical trials — most relevant to GPR27 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Varenicline (Chantix™) for the Treatment of Alcohol Dependence	PHASE2	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People	EARLY_PHASE1	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
Colonic Propionate, Appetite, and Weight Loss	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Gastroparesis Registry 3	nan	COMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Metabotropic Receptors For Glutamate Type 3 In Parkinson's	nan	UNKNOWN
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
The Role of Autoantibodies Against G-protein Coupled Receptors in Obesity	nan	NOT_YET_RECRUITING
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
Effects of Mulberry Juice on Inflammatory Status and Clinical Symptoms in Patients With General Anxiety Disorder	nan	UNKNOWN
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment	nan	NOT_YET_RECRUITING
Genetic Research in Schizophrenia Using DNA Markers and Clinical Phenotypes	nan	COMPLETED
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome	nan	ACTIVE_NOT_RECRUITING
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GPR27 binder may also engage these)

Protein	Name	Similarity
O54897	—	1.000	O54897 →
Q9JJH3	—	1.000	Q9JJH3 →
S1PR5	Sphingosine 1-phosphate receptor 5	0.977	landscape →
Q91X56	—	0.976	Q91X56 →
Q9JKM5	—	0.975	Q9JKM5 →
Q684M3	—	0.974	Q684M3 →
PTGER1	Prostaglandin E2 receptor EP1 subtype	0.959	landscape →
S1PR4	Sphingosine 1-phosphate receptor 4	0.957	landscape →
GALR3	Galanin receptor type 3	0.957	landscape →
Q9NS66	—	0.956	Q9NS66 →
Q5E9H8	—	0.955	Q5E9H8 →
Q8HYC3	—	0.953	Q8HYC3 →
Q9JJH2	—	0.953	Q9JJH2 →
Q6PI62	—	0.952	Q6PI62 →
Q9BGL8	—	0.951	Q9BGL8 →
P35375	—	0.950	P35375 →
MLNR	Motilin receptor	0.948	landscape →
UTS2R	Urotensin-2 receptor	0.948	landscape →
GPR6	G-protein coupled receptor 6	0.945	landscape →
AVPR2	Vasopressin V2 receptor	0.945	landscape →
P32307	—	0.945	P32307 →
O88626	—	0.944	O88626 →
P70597	—	0.944	P70597 →
Q96P69	—	0.943	Q96P69 →
O77808	—	0.942	O77808 →
Q6TLJ0	—	0.942	Q6TLJ0 →
O88853	—	0.942	O88853 →
Q00788	—	0.938	Q00788 →
Q7TQP2	—	0.937	Q7TQP2 →
HTR6	5-hydroxytryptamine receptor 6	0.937	landscape →