Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13660589 | 1.00 | HRH3 (0.70) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL13663364 | 1.00 | HRH3 (0.70) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL4295721 | 1.00 | HRH3 (0.70) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL13660593 | 0.86 | HRH3 (0.54) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL4291007 | 0.86 | HRH3 (0.54) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL12050664 | 0.83 | HRH3 (1.00) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL4098361 | 0.83 | HRH3 (1.00) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL4293401 | 0.79 | CYP2D6 (0.48) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL13660591 | 0.79 | CYP2D6 (0.48) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL4294247 | 0.77 | HRH3 (0.43) | HRH3KCNH2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090263322-A1 | OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES | APODACA RICHARD | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090263322-A1 | OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES | HRH4, HNMT, HRH1 | HRH3 7/4885KCNH2 470/4885CYP3A4 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.