Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.57 |
| ▸ | CTSD | P07339 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13645 | 0.77 | BACE1 (0.33) | BACE1CTSD | |
| SCHEMBL9166 | 0.72 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL9061 | 0.72 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL14321300 | 0.66 | BACE1 (0.65) | BACE1CTSDABL1TRPV1 | |
| SCHEMBL9702 | 0.66 | BACE1 (0.87) | BACE1CTSD | |
| SCHEMBL14321873 | 0.65 | BACE1 (0.69) | BACE1CTSD | |
| SCHEMBL17620320 | 0.64 | BACE1 (0.79) | BACE1CTSD | |
| SCHEMBL9396 | 0.64 | BACE1 (0.48) | BACE1CTSD | |
| SCHEMBL8994 | 0.63 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL14321762 | 0.63 | BACE1 (1.00) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |