Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13664 | 0.77 | BACE1 (0.57) | BACE1CTSD | |
| SCHEMBL9125 | 0.72 | BACE1 (0.62) | BACE1CTSD | |
| SCHEMBL17620302 | 0.72 | BACE1 (0.62) | BACE1CTSD | |
| SCHEMBL14324954 | 0.63 | ALDH1A1 (0.36) | — | |
| SCHEMBL14324953 | 0.63 | ALDH1A1 (0.36) | — | |
| SCHEMBL17620319 | 0.62 | BACE1 (0.59) | BACE1CTSD | |
| SCHEMBL15541599 | 0.56 | SIGMAR1 (0.38) | SIGMAR1 | |
| SCHEMBL18555901 | 0.55 | CTSC (0.43) | SIGMAR1 | |
| SCHEMBL16464588 | 0.54 | CHIA (0.39) | — | |
| SCHEMBL16464589 | 0.54 | CHIA (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |