Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL928205 | 0.77 | LMNA (0.67) | CYP1A2LMNAKMT2AMEN1PDE3A | |
| SCHEMBL4390590 | 0.77 | CCR1 (0.46) | CYP1A2LMNAPOLBTP53HPGD | |
| SCHEMBL1456234 | 0.72 | CYP1A2 (0.58) | CYP1A2LMNAKMT2AMEN1PDE3A | |
| SCHEMBL31096513 | 0.72 | CYP1A2 (0.58) | CYP1A2LMNAKMT2AMEN1PDE3A | |
| SCHEMBL31096516 | 0.72 | CYP1A2 (0.58) | CYP1A2LMNAKMT2AMEN1PDE3A | |
| SCHEMBL24240198 | 0.70 | CYP1A2 (0.47) | CYP1A2LMNAKMT2AMEN1PDE3A | |
| SCHEMBL3452908 | 0.69 | LMNA (0.80) | CYP1A2LMNAKMT2AMEN1PDE3A | |
| SCHEMBL20204018 | 0.68 | LMNA (0.43) | CYP1A2LMNAKMT2AMEN1PDE3A | |
| SCHEMBL3751899 | 0.68 | CYP1A2 (0.59) | CYP1A2LMNAKMT2AMEN1PDE3A | |
| SCHEMBL3410634 | 0.67 | CYP1A2 (0.47) | CYP1A2LMNAKMT2AMEN1PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009126672-A2 | 2-ALKYNYL-6-PYRIDIN-2-YL-PYRIDAZINONES, 2-ALKYNYL-6-PYRIDIN-2-YL-DIHYDROPYRIDAZINONES, 2-ALKYNYL-6-PYRIMIDIN-2-YL-PYRIDAZINONES AND 2-ALKYNYL-6-PYRIMIDIN-2-YL-DIHYDROPYRIDAZINONES AND THEIR USE AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2009-10-15 | — | — | WO | disclosed |