Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 7/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13248779 | 0.71 | HTT (0.50) | HTTESR1PKMSMN1; SMN2TAS1R3 | |
| SCHEMBL13911938 | 0.71 | ESR1 (0.42) | HTTLMNATP53MAPK1ESR1 | |
| SCHEMBL721202 | 0.69 | ESR1 (0.41) | HTTLMNATP53MAPK1GAA | |
| Hydrochloric Acid SCHEMBL7942166 | 0.69 | HTT (0.34) | HTTLMNATP53MAPK1GAA | |
| SCHEMBL7579018 | 0.67 | ESR1 (0.39) | HTTGAAESR1PKMSMN1; SMN2 | |
| SCHEMBL707937 | 0.67 | ESR1 (0.39) | HTTESR1 | |
| Water SCHEMBL1285779 | 0.67 | ESR1 (0.39) | HTTGAAESR1PKMSMN1; SMN2 | |
| SCHEMBL10671409 | 0.67 | ESR1 (0.39) | HTTESR1 | |
| SCHEMBL707936 | 0.67 | ESR1 (0.39) | HTTESR1 | |
| SCHEMBL9040401 | 0.67 | ESR1 (0.44) | HTTMAPK1ESR1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009126782-A1 | HISTAMINE H3 RECEPTOR LIGANDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2009-10-15 | — | — | WO | disclosed |