Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.46 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.46 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13665312 | 0.91 | MAPT (0.48) | MAPTHTTTPSAB1TPSD1TPSG1 | |
| SCHEMBL30841401 | 0.86 | SYK (0.48) | MAPTSYKLMNASMN1; SMN2POLB | |
| SCHEMBL21460902 | 0.83 | MAPT (0.51) | MAPTHTTTPSAB1TPSD1TPSG1 | |
| SCHEMBL21460905 | 0.83 | MAPT (0.51) | MAPTHTTTPSAB1TPSD1TPSG1 | |
| SCHEMBL13664874 | 0.83 | ITGA4 (0.43) | POLBKLK5 | |
| SCHEMBL30841335 | 0.81 | SYK (0.44) | MAPTSYKPOLBMAPK1KLK5 | |
| SCHEMBL31187921 | 0.80 | MAPT (0.49) | MAPTHTTTPSAB1TPSD1TPSG1 | |
| SCHEMBL30306840 | 0.79 | SIRT2 (0.50) | MAPTTPSAB1TPSD1TPSG1SYK | |
| SCHEMBL22123600 | 0.79 | HTT (0.53) | MAPTHTTTPSAB1TPSD1TPSG1 | |
| SCHEMBL9772167 | 0.78 | MAPT (0.56) | MAPTHTTTPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009119528-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2009-10-01 | — | — | WO | disclosed |