ITGA4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL84711	0.88	20/20
SCHEMBL92407	0.88	20/20
SCHEMBL84713	0.88	20/20
SCHEMBL85320	0.88	20/20
SCHEMBL85446	0.87	20/20
SCHEMBL84715	0.85	20/20
SCHEMBL84854	0.85	20/20
SCHEMBL85158	0.85	20/20
SCHEMBL85443	0.85	20/20
SCHEMBL92243	0.84	20/20
SCHEMBL84974	0.84	20/20
SCHEMBL84975	0.84	20/20
SCHEMBL85258	0.84	20/20
SCHEMBL85348	0.84	20/20
SCHEMBL85418	0.84	20/20
SCHEMBL85648	0.84	20/20
SCHEMBL85342	0.84	20/20
SCHEMBL85254	0.83	20/20
SCHEMBL85337	0.83	20/20
SCHEMBL84968	0.83	20/20

Clinical trials — most relevant to ITGA4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
99mTc-3PRGD2 SPECT/CT for Integrin Imaging of Lung Cancer	PHASE3	COMPLETED
68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Angiogenesis in Ischemic Heart Disease	PHASE2	UNKNOWN
Monoclonal Antibody Therapy in Treating Patients With Advanced Colorectal Cancer	PHASE1/PHASE2	COMPLETED
Cilengitide in Treating Patients With Prostate Cancer	PHASE2	COMPLETED
Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BIIB107 in Healthy Adult Participants	PHASE1	COMPLETED
Vedolizumab (Anti-alpha4beta7) in Subjects With HIV Infection Undergoing Analytical Treatment Interruption	PHASE1	COMPLETED
Safety/Biomarker Study of CNTO 95 and Avastin in Solid Tumors	PHASE1	COMPLETED
A Gene Therapy Trial to Evaluate the Safety and Efficacy of RP-L201 in Subjects With Leukocyte Adhesion Deficiency-I	PHASE1	WITHDRAWN
68Ga-NOTA-PRGD2 PET/CT in Patients With Lung Injury and Pulmonary Fibrosis	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Diagnosis and Evaluation of Glioma	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Patients With Rheumatoid Arthritis	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Evaluation of Stroke	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Evaluation of Myocardial Infarction	EARLY_PHASE1	UNKNOWN
99mTc-3PRGD2 SPECT/CT in Rheumatoid Arthritis Patients	EARLY_PHASE1	COMPLETED
68Ga-BNOTA-PRGD2 PET/CT in Healthy Volunteers and Lung Cancer Patients	EARLY_PHASE1	UNKNOWN
Anti-αIIbβ3 Immunization in Glanzmann Thrombasthenia: Prevalence and Associated Risk Factors: Thrombasthenia Anti-αIIbβ3 Antibodies Study (TAAS)	nan	COMPLETED
The Role of CD4+ T Cell Subsets in the Mechanism of Action of Vedolizumab in Ulcerative Colitis	nan	UNKNOWN
Angiogenesis and Fibrosis in Aortic Stenosis	nan	COMPLETED
Angiogenesis and Fibrosis in Myocardial Infarction	nan	COMPLETED
The Role of Platelet Surface α2β1 Integrin Expression as a Risk Factor in Thrombotic and/or Bleeding Complications	nan	COMPLETED
IMaging Pilot Study of the αvβ6 Integrin Radiotracer [18F]-A20FMDV2 in PAtients With Solid Cancer Types	nan	COMPLETED
Clinical Study of 18F-FAPI-RGD in Ovarian Cancer	nan	COMPLETED
68Ga-NODAGA-RGD PET in Patients With an Occluded Coronary Artery	nan	UNKNOWN
Clinical Study of 18F-FAPI-RGD in Breast Tumors	nan	COMPLETED
Integrin αvβ6-targeted PET in Malignant Tumors	nan	RECRUITING
Serum Talin-1 and Cripto-1 in Colorectal Cancer	nan	NOT_YET_RECRUITING
Eosinophil β1 Integrin Activation as a Biomarker for Eosinophilic Esophagitis	nan	COMPLETED
T Lymphocyte Subsets in Ulcerative Colitis	nan	NOT_YET_RECRUITING
The Role of the Novel 99mTc-NC100692 Tracer in Patients at High Risk or Known Breast Cancer	nan	UNKNOWN
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ITGA4 binder may also engage these)

Protein	Name	Similarity
Q00651	—	1.000	Q00651 →
Q13797	—	0.996	Q13797 →
B8JK39	—	0.995	B8JK39 →
ITGA8	Integrin alpha-8 [Cleaved into: Integrin alph	0.993	landscape →
P26009	—	0.992	P26009 →
P61622	—	0.990	P61622 →
Q62469	—	0.989	Q62469 →
A2ARA8	—	0.989	A2ARA8 →
P53710	—	0.986	P53710 →
Q9UKX5	—	0.985	Q9UKX5 →
ITGA2	Integrin alpha-2	0.984	landscape →
Q62470	—	0.983	Q62470 →
P38570	—	0.982	P38570 →
Q91687	—	0.982	Q91687 →
P26006	—	0.982	P26006 →
P43406	—	0.981	P43406 →
F1MMS9	—	0.979	F1MMS9 →
ITGAV	Integrin alpha-V	0.979	landscape →
P17852	—	0.979	P17852 →
P80746	—	0.979	P80746 →
P26008	—	0.978	P26008 →
Q06274	—	0.977	Q06274 →
O94985	—	0.976	O94985 →
ITGAL	Integrin alpha-L	0.976	landscape →
E1BFX5	—	0.975	E1BFX5 →
O42237	—	0.975	O42237 →
Q14563	—	0.975	Q14563 →
Q13683	—	0.975	Q13683 →
Q9W686	—	0.975	Q9W686 →
Q63258	—	0.974	Q63258 →