Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | HPD | P32754 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13666358 | 0.94 | MAPT (0.52) | TP53MAPTNPC1RAB9AKDR | |
| SCHEMBL13666876 | 0.93 | KDR (0.52) | TP53MAPTNPC1RAB9AKDR | |
| SCHEMBL13666337 | 0.92 | MAPT (0.47) | TP53MAPTNPC1RAB9AKDR | |
| SCHEMBL13666413 | 0.89 | MAPT (0.47) | TP53MAPTNPC1RAB9AKDR | |
| SCHEMBL13666856 | 0.89 | KDR (0.53) | TP53MAPTNPC1RAB9AKDR | |
| SCHEMBL13666412 | 0.88 | TP53 (0.52) | TP53MAPTNPC1RAB9AKDR | |
| SCHEMBL13666415 | 0.88 | KDR (0.55) | TP53MAPTNPC1RAB9AKDR | |
| SCHEMBL13666852 | 0.88 | RAB9A (0.52) | TP53MAPTNPC1RAB9AKDR | |
| SCHEMBL13666677 | 0.88 | KDR (0.46) | TP53MAPTNPC1RAB9AKDR | |
| SCHEMBL13666673 | 0.87 | TP53 (0.49) | TP53MAPTNPC1RAB9AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009119776-A1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | 武田薬品工業株式会社 (JP) | 2009-10-01 | — | — | WO | disclosed |