Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 7/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 5/20 | 0.39 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015464 | 0.87 | HSD11B1 (0.55) | HSD11B1MAPK8 | |
| SCHEMBL1018098 | 0.83 | HSD11B1 (0.54) | HSD11B1JAK3JAK1 | |
| SCHEMBL1016192 | 0.81 | HSD11B1 (0.53) | HSD11B1 | |
| SCHEMBL1014864 | 0.77 | HSD11B1 (0.53) | HSD11B1 | |
| SCHEMBL14667326 | 0.75 | HSD11B1 (0.47) | HSD11B1JAK3JAK1MAPK8MAPK9 | |
| SCHEMBL14667125 | 0.74 | MAPK8 (0.64) | SYKMAPK8MAPK9 | |
| SCHEMBL14667123 | 0.72 | JAK3 (0.40) | JAK3JAK2JAK1SYK | |
| SCHEMBL14667158 | 0.72 | MAPK8 (0.51) | SYKMAPK8MAPK9 | |
| SCHEMBL6195932 | 0.71 | PARP10 (0.41) | CD38PARP10PARP15 | |
| SCHEMBL1014981 | 0.71 | HSD11B1 (1.00) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130496-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | WO | disclosed |