Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 7/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | AGXT | P21549 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7240044 | 0.83 | MAOB (0.53) | APPMAOBNPC1RAB9APOLB | |
| SCHEMBL11931427 | 0.82 | GRM5 (0.56) | GRM5APPMAOBNPC1RAB9A | |
| SCHEMBL12221468 | 0.81 | APP (0.49) | APPMAOBNPC1RAB9APOLB | |
| SCHEMBL9618281 | 0.79 | APP (0.67) | APPMAOBNPC1RAB9APOLB | |
| SCHEMBL12221466 | 0.79 | NPC1 (0.51) | GRM5APPMAOBNPC1RAB9A | |
| SCHEMBL22119929 | 0.79 | APP (0.50) | APPMAOBNPC1RAB9APOLB | |
| SCHEMBL12221463 | 0.79 | NPC1 (0.66) | APPMAOBNPC1RAB9APOLB | |
| SCHEMBL12221469 | 0.79 | APP (0.48) | APPMAOBNPC1RAB9APOLB | |
| SCHEMBL29371430 | 0.79 | APP (0.50) | APPMAOBNPC1RAB9APOLB | |
| SCHEMBL18475585 | 0.77 | APP (0.69) | APPMAOBNPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132087-A1 | THIOPHENE DERIVATIVES USEFUL AS OCULAR HYPOTENSIVE AGENTS | ALLERGAN, INC. (US) | 2009-10-29 | — | — | WO | disclosed |