Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 17/20 | 0.79 |
| ▸ | EGFR | P00533 | 3/20 | 0.68 |
| ▸ | MET | P08581 | 3/20 | 0.68 |
| ▸ | SRC | P12931 | 3/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.68 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.68 |
| ▸ | ERN1 | O75460 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.68 |
| ▸ | FYN | P06241 | 1/20 | 0.68 |
| ▸ | YES1 | P07947 | 1/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.68 |
| ▸ | FER | P16591 | 1/20 | 0.68 |
| ▸ | MARK3 | P27448 | 1/20 | 0.68 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.68 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.68 |
| ▸ | CSK | P41240 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13667704 | 0.92 | AXL (0.68) | AXLEGFRMETSRCPLK4 | |
| SCHEMBL13667556 | 0.90 | AXL (0.70) | AXLEGFRMETSRCPLK4 | |
| SCHEMBL13667535 | 0.89 | AXL (0.66) | AXLEGFRMETSRCKIT | |
| SCHEMBL1591147 | 0.88 | AXL (1.00) | AXLEGFRMETSRCPLK4 | |
| SCHEMBL10328536 | 0.88 | AXL (0.64) | AXLEGFRMETSRCKIT | |
| SCHEMBL10328541 | 0.88 | AXL (0.64) | AXLEGFRMETSRCKIT | |
| SCHEMBL1546564 | 0.86 | AXL (1.00) | AXLEGFRMETSRCPLK4 | |
| SCHEMBL13667526 | 0.85 | AXL (0.62) | AXLEGFRMETSRCPLK4 | |
| SCHEMBL1546615 | 0.84 | AXL (1.00) | AXLEGFRMETSRCPLK4 | |
| SCHEMBL13667553 | 0.83 | AXL (0.64) | AXLEGFRMETSRCPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127417-A1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2009-10-22 | — | — | WO | disclosed |