Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 15/20 | 0.64 |
| ▸ | MET | P08581 | 6/20 | 0.64 |
| ▸ | EGFR | P00533 | 5/20 | 0.64 |
| ▸ | SRC | P12931 | 3/20 | 0.64 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13667704 | 0.93 | AXL (0.68) | AXLMETEGFRSRC | |
| SCHEMBL13667535 | 0.91 | AXL (0.66) | AXLMETEGFRSRCKIT | |
| SCHEMBL10328536 | 0.90 | AXL (0.64) | AXLMETEGFRSRCKIT | |
| SCHEMBL13667556 | 0.89 | AXL (0.70) | AXLMETEGFRSRC | |
| SCHEMBL13667703 | 0.88 | AXL (0.79) | AXLMETEGFRSRCKIT | |
| SCHEMBL12704879 | 0.83 | AXL (0.79) | AXLMETEGFRSRC | |
| SCHEMBL13667702 | 0.81 | AXL (0.80) | AXLMETEGFRSRC | |
| SCHEMBL1591619 | 0.81 | AXL (0.86) | AXLMETEGFRSRC | |
| SCHEMBL13667534 | 0.80 | AXL (0.66) | AXLMETEGFRSRC | |
| SCHEMBL13667553 | 0.80 | AXL (0.64) | AXLMETEGFRSRCKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | disclosed |