Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8282913 | 0.84 | ALDH1A1 (0.48) | ALDH1A1HPGDHTTGRM5 | |
| SCHEMBL4433042 | 0.83 | ALDH1A1 (0.52) | ALDH1A1HPGDHTTGRM5 | |
| SCHEMBL4421502 | 0.82 | POLB (0.57) | POLBALDH1A1HTTGRM5 | |
| Hydrochloric Acid SCHEMBL4432944 | 0.80 | POLB (0.54) | POLBALDH1A1HTT | |
| SCHEMBL5035975 | 0.78 | POLB (0.52) | POLBALDH1A1HTT | |
| SCHEMBL4433327 | 0.77 | POLB (0.53) | POLB | |
| SCHEMBL4433648 | 0.76 | CYP2C19 (0.51) | POLBALDH1A1HPGDHTTGRM5 | |
| SCHEMBL4423861 | 0.75 | POLB (0.51) | POLB | |
| SCHEMBL4427115 | 0.75 | POLB (0.56) | POLBALDH1A1HTTGRM5 | |
| SCHEMBL4421913 | 0.73 | POLB (0.57) | POLBALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598384-B2 | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-10-06 | — | — | US | disclosed |
| US-7598384-B2 | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-10-06 | — | — | US | disclosed |