Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623051 | 0.86 | IKBKB (0.39) | GRM5IKBKB | |
| SCHEMBL13669928 | 0.78 | CLK2 (0.38) | GRM5IKBKB | |
| SCHEMBL1025282 | 0.78 | FFAR1 (0.45) | GRM5IKBKBKDM4EMEN1NPC1 | |
| SCHEMBL13623044 | 0.71 | IRAK4 (0.42) | IKBKB | |
| SCHEMBL13623024 | 0.70 | CYP17A1 (0.40) | GRM5IKBKBALDH1A1HDAC6 | |
| SCHEMBL4711036 | 0.70 | GRM5 (0.67) | GRM5KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL13622710 | 0.69 | ALDH1A1 (0.47) | IKBKBALDH1A1SMN1; SMN2HDAC6 | |
| SCHEMBL13623057 | 0.67 | NAMPT (0.43) | IKBKB | |
| SCHEMBL1026078 | 0.66 | CSNK2A2 (0.41) | GRM5KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL4968126 | 0.65 | CYP3A4 (0.58) | IKBKBALDH1A1CYP3A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |