Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705570 | 0.82 | MAPT (0.37) | KDM4EALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL4701697 | 0.82 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL7999907 | 0.80 | KDM4E (0.63) | KDM4EALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL5242785 | 0.78 | ALDH1A1 (0.36) | KDM4EALDH1A1GLASMN1; SMN2HSD17B10 | |
| SCHEMBL4703102 | 0.74 | KDM4E (0.35) | KDM4EALDH1A1SMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL4705550 | 0.73 | KDM4E (0.42) | KDM4ESMN1; SMN2GAAPOLB | |
| SCHEMBL14955079 | 0.73 | SMN1; SMN2 (0.63) | KDM4EALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL14954856 | 0.72 | MAPT (0.50) | KDM4EALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL29741226 | 0.71 | SMN1; SMN2 (0.59) | KDM4EALDH1A1GLASMN1; SMN2TP53 | |
| SCHEMBL4705401 | 0.69 | POLB (0.37) | KDM4EALDH1A1SMN1; SMN2HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608643-B2 | Compounds for inhibiting KSP kinesin activity | SCHERING CORPORATION (US) | 2009-10-27 | — | — | US | disclosed |