Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1365279 | 0.99 | KIT (0.49) | KITATRAURKBJAK2PLK4 | |
| SCHEMBL1367961 | 0.93 | PIK3CA (0.47) | KITATRAURKBJAK2PLK4 | |
| SCHEMBL1368105 | 0.82 | TBK1 (0.51) | KITFGFR1PIK3CAMTORSYK | |
| Hydrochloric Acid SCHEMBL1365702 | 0.81 | TBK1 (0.50) | KITFGFR1PIK3CAMTORSYK | |
| SCHEMBL1367311 | 0.79 | MAPK14 (0.55) | KITATRAURKBJAK2PLK4 | |
| Hydrochloric Acid SCHEMBL1365281 | 0.79 | MAPK14 (0.54) | KITATRAURKBJAK2PLK4 | |
| SCHEMBL1368092 | 0.78 | PIK3CA (0.48) | KITPIK3CAMTORCCNT1CCND1 | |
| SCHEMBL1367963 | 0.77 | SMN1; SMN2 (0.56) | AURKBJAK2PLK4MAP4K4ROS1 | |
| SCHEMBL4119706 | 0.77 | MAPK14 (0.59) | KITKDRBRAFMAPK14JAK3 | |
| SCHEMBL1368109 | 0.77 | BRAF (0.52) | KITAURKBJAK2PLK4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067599-B2 | Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2011-11-29 | — | — | US | claimed |
| US-8067599-B2 | Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2011-11-29 | — | — | US | disclosed |