Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10246135 | 0.88 | NPC1 (0.41) | NPC1NPSR1GAAL3MBTL1LMNA | |
| SCHEMBL3442720 | 0.88 | NPC1 (0.46) | NPC1NPSR1GAAL3MBTL1LMNA | |
| SCHEMBL3442722 | 0.86 | NPC1 (0.41) | NPC1NPSR1GAAL3MBTL1LMNA | |
| SCHEMBL10246492 | 0.86 | KMT2A (0.45) | NPC1NPSR1GAAL3MBTL1LMNA | |
| SCHEMBL700177 | 0.85 | NPC1 (0.43) | NPC1NPSR1GAAL3MBTL1LMNA | |
| SCHEMBL10246158 | 0.84 | NPC1 (0.44) | NPC1NPSR1GAAL3MBTL1LMNA | |
| SCHEMBL13695348 | 0.74 | NPC1 (0.53) | NPC1NPSR1GAAL3MBTL1LMNA | |
| SCHEMBL10246209 | 0.68 | NPC1 (0.48) | NPC1NPSR1GAAL3MBTL1LMNA | |
| SCHEMBL5461127 | 0.66 | NPC1 (0.46) | NPC1NPSR1GAAL3MBTL1LMNA | |
| SCHEMBL10246235 | 0.66 | LMNA (0.40) | NPC1NPSR1GAAL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009124733-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-10-15 | — | — | WO | disclosed |