Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 3/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL864911 | 0.84 | IDO1 (0.47) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL5776968 | 0.84 | IDO1 (0.54) | IDO1TSHRTAAR1TACR1CACNA1F | |
| SCHEMBL2793814 | 0.83 | TAAR1 (0.43) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL10200704 | 0.83 | IDO1 (0.45) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL10959537 | 0.81 | IDO1 (0.44) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL29467109 | 0.81 | IDO1 (0.44) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL129085 | 0.81 | RXRA (0.45) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL2793246 | 0.80 | TAAR1 (0.41) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL2795945 | 0.80 | TAAR1 (0.41) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL806196 | 0.79 | TAAR1 (0.56) | IDO1TSHRMAPK1MAOBTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601725-B2 | Thienopyrimidines useful as Aurora kinase inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | disclosed |