Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.81 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13672608 | 0.90 | EGFR (1.00) | EGFRFLT1 | |
| SCHEMBL14461353 | 0.88 | EGFR (0.77) | EGFRFLT1CDK1 | |
| SCHEMBL13674981 | 0.81 | EGFR (0.81) | EGFR | |
| SCHEMBL13675158 | 0.81 | EGFR (0.81) | EGFRCDK1 | |
| SCHEMBL13674980 | 0.80 | EGFR (0.82) | EGFRCDK1 | |
| SCHEMBL13675052 | 0.80 | EGFR (0.59) | EGFRCDK1 | |
| SCHEMBL13675194 | 0.80 | EGFR (0.70) | EGFRCDK1 | |
| SCHEMBL13674979 | 0.80 | EGFR (0.70) | EGFR | |
| SCHEMBL13672604 | 0.80 | EGFR (1.00) | EGFR | |
| SCHEMBL13675161 | 0.79 | EGFR (0.82) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605154-B2 | ATP-protein kinase inhibitors; cytomegalovirus; contraceptive agents; cancer; N7-(3-ethynyl-phenyl)-N2-(4-piperidin-1-ylmethyl-phenyl)-thiazolo[4,5-d]pyrimidine-2,7-diamine | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-20 | — | — | US | disclosed |