Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.74 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13672688 | 0.86 | EGFR (1.00) | EGFRCDK1 | |
| SCHEMBL13675197 | 0.86 | EGFR (0.75) | EGFRTRPV1CHRNA7 | |
| SCHEMBL13672701 | 0.85 | EGFR (1.00) | EGFRTRPV1CDK1 | |
| SCHEMBL13672700 | 0.85 | EGFR (0.74) | EGFRTRPV1 | |
| SCHEMBL13674977 | 0.85 | EGFR (0.65) | EGFRHTTMAPK1TSHRRAB9A | |
| SCHEMBL13672705 | 0.81 | EGFR (0.84) | EGFRTRPV1CDK1 | |
| SCHEMBL13675243 | 0.80 | EGFR (0.77) | EGFR | |
| SCHEMBL13674985 | 0.79 | EGFR (0.75) | EGFRTRPV1CHRNA7 | |
| SCHEMBL13672699 | 0.79 | EGFR (1.00) | EGFRTRPV1CDK1 | |
| SCHEMBL5134221 | 0.76 | EGFR (1.00) | EGFRHTTRAB9ATRPV1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605154-B2 | ATP-protein kinase inhibitors; cytomegalovirus; contraceptive agents; cancer; N7-(3-ethynyl-phenyl)-N2-(4-piperidin-1-ylmethyl-phenyl)-thiazolo[4,5-d]pyrimidine-2,7-diamine | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-20 | — | — | US | disclosed |