Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TOP1 | P11387 | 15/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18265579 | 1.00 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDHTT | |
| SCHEMBL13675227 | 0.96 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDHTT | |
| SCHEMBL2602723 | 0.96 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDHTT | |
| SCHEMBL13672589 | 0.96 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDHTT | |
| SCHEMBL13675189 | 0.96 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDHTT | |
| SCHEMBL13672591 | 0.96 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDHTT | |
| SCHEMBL18265581 | 0.95 | KDM4E (0.49) | KDM4EGLAALDH1A1HPGDHTT | |
| SCHEMBL20807097 | 0.86 | TOP1 (0.47) | KDM4EGLAALDH1A1HPGDHTT | |
| SCHEMBL20807206 | 0.86 | TOP1 (0.47) | KDM4EGLAALDH1A1HPGDHTT | |
| SCHEMBL18774804 | 0.86 | TOP1 (0.47) | KDM4EGLAALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605262-B2 | Podophyllotoxin derivatives | SUTTER WEST BAY HOSPITALS (US) | 2009-10-20 | — | — | US | disclosed |
| US-20080113941-A1 | Podophyllotoxin Derivatives | CALIFORNIA PACIFIC MEDICAL CENTER | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113941-A1 | Podophyllotoxin Derivatives | APEH, DAGLA, DPY30 | KDM4E 37/4885GLA 1195/4885ALDH1A1 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.