Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TOP1 | P11387 | 11/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675189 | 1.00 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL13672589 | 1.00 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL2602723 | 1.00 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL13672591 | 1.00 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL18265581 | 0.97 | KDM4E (0.49) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL18265579 | 0.96 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL13675190 | 0.96 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL20807097 | 0.89 | TOP1 (0.47) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL20807206 | 0.89 | TOP1 (0.47) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL18774804 | 0.89 | TOP1 (0.47) | KDM4EGLAALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605262-B2 | Podophyllotoxin derivatives | SUTTER WEST BAY HOSPITALS (US) | 2009-10-20 | — | — | US | disclosed |