Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | VDR | P11473 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13672897 | 0.86 | HDAC3 (0.36) | VDRHDAC3HDAC6 | |
| SCHEMBL13366780 | 0.85 | VDR (0.50) | ARVDRHDAC3 | |
| SCHEMBL13675225 | 0.76 | ESR1 (0.45) | ESR1ESR2ARVDR | |
| SCHEMBL3392747 | 0.73 | ESR1 (0.44) | ESR1ESR2ARVDRHDAC3 | |
| SCHEMBL13675224 | 0.72 | ESR1 (0.54) | ESR1ESR2ARVDR | |
| SCHEMBL3391928 | 0.70 | ESR1 (0.46) | ESR1ESR2ARVDR | |
| SCHEMBL13366679 | 0.70 | ESR1 (0.45) | ESR1ESR2ARVDR | |
| SCHEMBL3393109 | 0.69 | ESR1 (0.53) | ESR1ESR2ARVDRHDAC3 | |
| SCHEMBL3392743 | 0.68 | ESR1 (0.45) | ESR1ESR2ARVDRHDAC3 | |
| SCHEMBL15076980 | 0.67 | ESR1 (0.47) | ESR1ESR2ARVDRHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601850-B2 | less hypercalcemic than 1a,25 dihydroxy vitamin D3; bone disorders, psoriasis | ELI LILLY AND COMPANY (US) | 2009-10-13 | — | — | US | disclosed |