Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 20/20 | 0.82 |
| ▸ | CDK2 | P24941 | 20/20 | 0.82 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.65 |
| ▸ | CCNK | O75909 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | CDK4 | P11802 | 1/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.62 |
| ▸ | CCND1 | P24385 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | CDK9 | P50750 | 1/20 | 0.62 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.62 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.62 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.62 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5725190 | 0.88 | CCNA2 (0.91) | CCNA2CDK2CCNE1GSK3BCDK5 | |
| SCHEMBL6188285 | 0.86 | CCNA2 (0.78) | CCNA2CDK2CCNE1CCNKCDK1 | |
| SCHEMBL4479206 | 0.86 | CCNA2 (0.77) | CCNA2CDK2CCNE1CCNKCDK1 | |
| SCHEMBL6191118 | 0.85 | CCNA2 (0.75) | CCNA2CDK2CCNE1CCNKCDK1 | |
| SCHEMBL6196988 | 0.85 | CCNA2 (0.75) | CCNA2CDK2CCNE1CCNKCDK1 | |
| SCHEMBL6194405 | 0.84 | CCNA2 (0.73) | CCNA2CDK2CCNE1CCNKCDK1 | |
| SCHEMBL7757552 | 0.83 | CCNA2 (0.76) | CCNA2CDK2GSK3BCDK5CDK5R1 | |
| SCHEMBL20142363 | 0.82 | CCNA2 (0.89) | CCNA2CDK2CCNE1CDK5CDK5R1 | |
| SCHEMBL5725900 | 0.82 | CCNA2 (0.73) | CCNA2CDK2CCNE1CCNKCDK1 | |
| SCHEMBL6699601 | 0.81 | CCNA2 (0.72) | CCNA2CDK2CCNE1CCNKCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605154-B2 | ATP-protein kinase inhibitors; cytomegalovirus; contraceptive agents; cancer; N7-(3-ethynyl-phenyl)-N2-(4-piperidin-1-ylmethyl-phenyl)-thiazolo[4,5-d]pyrimidine-2,7-diamine | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-20 | — | — | US | disclosed |