Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.79 |
| ▸ | CDK1 | P06493 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675045 | 0.88 | EGFR (0.74) | EGFRCDK1MEN1KMT2A | |
| SCHEMBL13672682 | 0.88 | EGFR (1.00) | EGFRCDK1SOS1 | |
| SCHEMBL14462118 | 0.85 | EGFR (0.75) | EGFRCDK1 | |
| SCHEMBL13672688 | 0.85 | EGFR (1.00) | EGFRCDK1MEN1KMT2A | |
| SCHEMBL13675242 | 0.84 | EGFR (0.57) | EGFRCDK1 | |
| SCHEMBL5066710 | 0.83 | EGFR (0.83) | EGFRCDK1 | |
| SCHEMBL13675044 | 0.83 | EGFR (0.75) | EGFRCDK1 | |
| SCHEMBL5134221 | 0.83 | EGFR (1.00) | EGFRCDK1MEN1KMT2A | |
| SCHEMBL13672683 | 0.83 | EGFR (1.00) | EGFRCDK1 | |
| SCHEMBL5069434 | 0.82 | EGFR (1.00) | EGFRCDK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605154-B2 | ATP-protein kinase inhibitors; cytomegalovirus; contraceptive agents; cancer; N7-(3-ethynyl-phenyl)-N2-(4-piperidin-1-ylmethyl-phenyl)-thiazolo[4,5-d]pyrimidine-2,7-diamine | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-20 | — | — | US | disclosed |