Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.57 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13672635 | 0.90 | EGFR (0.73) | EGFRCDK1 | |
| SCHEMBL14461356 | 0.88 | EGFR (0.56) | EGFRCDK1CCNB2CCNE2CDK4 | |
| SCHEMBL13675235 | 0.85 | EGFR (0.60) | EGFRCDK1 | |
| SCHEMBL13675240 | 0.84 | EGFR (0.79) | EGFRCDK1 | |
| SCHEMBL13675047 | 0.83 | EGFR (0.59) | EGFRCDK1 | |
| SCHEMBL5069412 | 0.81 | EGFR (0.57) | EGFRCDK1 | |
| SCHEMBL13672628 | 0.81 | EGFR (0.69) | EGFRCDK1 | |
| SCHEMBL13675038 | 0.79 | EGFR (0.83) | EGFRCDK1 | |
| SCHEMBL13675052 | 0.77 | EGFR (0.59) | EGFRCDK1 | |
| SCHEMBL13675035 | 0.75 | EGFR (0.81) | EGFRCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605154-B2 | ATP-protein kinase inhibitors; cytomegalovirus; contraceptive agents; cancer; N7-(3-ethynyl-phenyl)-N2-(4-piperidin-1-ylmethyl-phenyl)-thiazolo[4,5-d]pyrimidine-2,7-diamine | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-20 | — | — | US | disclosed |