Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.51 |
| ▸ | VDR | P11473 | 9/20 | 0.46 |
| ▸ | AR | P10275 | 4/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16183054 | 0.83 | HDAC3 (0.65) | HDAC3HDAC6VDRARHDAC1 | |
| SCHEMBL13672785 | 0.82 | HDAC3 (0.68) | HDAC3HDAC6VDRARHDAC1 | |
| SCHEMBL3394913 | 0.82 | HDAC3 (0.68) | HDAC3HDAC6VDRARHDAC1 | |
| SCHEMBL13675118 | 0.81 | HDAC3 (0.63) | HDAC3HDAC6VDRAR | |
| SCHEMBL3395685 | 0.81 | HDAC3 (0.63) | HDAC3HDAC6VDRAR | |
| SCHEMBL13366824 | 0.80 | HDAC3 (0.71) | HDAC3HDAC6VDRARHDAC1 | |
| SCHEMBL3395284 | 0.80 | HDAC3 (0.71) | HDAC3HDAC6VDRARHDAC1 | |
| SCHEMBL13366715 | 0.80 | HDAC3 (0.71) | HDAC3HDAC6VDRARHDAC1 | |
| SCHEMBL3421889 | 0.79 | HDAC3 (0.64) | HDAC3HDAC6VDRARHDAC1 | |
| SCHEMBL3393099 | 0.79 | HDAC3 (0.66) | HDAC3HDAC6VDRARHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601850-B2 | less hypercalcemic than 1a,25 dihydroxy vitamin D3; bone disorders, psoriasis | ELI LILLY AND COMPANY (US) | 2009-10-13 | — | — | US | disclosed |