Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.62 |
| ▸ | AURKA | O14965 | 12/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.59 |
| ▸ | KDR | P35968 | 8/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.59 |
| ▸ | SRC | P12931 | 6/20 | 0.59 |
| ▸ | GSK3B | P49841 | 6/20 | 0.59 |
| ▸ | GSK3A | P49840 | 4/20 | 0.59 |
| ▸ | ABL1 | P00519 | 3/20 | 0.59 |
| ▸ | LCK | P06239 | 3/20 | 0.59 |
| ▸ | CSF1R | P07333 | 3/20 | 0.59 |
| ▸ | RET | P07949 | 3/20 | 0.59 |
| ▸ | FLT3 | P36888 | 3/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.59 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.59 |
| ▸ | KIT | P10721 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | TYK2 | P29597 | 2/20 | 0.59 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675364 | 0.84 | ITK (0.56) | ITKAURKAAURKBKDRFGFR1 | |
| SCHEMBL10122874 | 0.84 | AURKA (0.66) | ITKAURKAAURKBKDRFGFR1 | |
| SCHEMBL10122920 | 0.82 | AURKA (0.65) | ITKAURKAAURKBKDRFGFR1 | |
| SCHEMBL10122908 | 0.82 | AURKA (0.58) | ITKAURKAAURKBKDRFGFR1 | |
| SCHEMBL10123180 | 0.81 | AURKA (0.64) | ITKAURKAAURKBKDRFGFR1 | |
| SCHEMBL13675323 | 0.81 | AURKA (0.64) | ITKAURKAAURKBKDRFGFR1 | |
| SCHEMBL10122913 | 0.81 | AURKA (0.60) | ITKAURKAAURKBKDRFGFR1 | |
| SCHEMBL10122950 | 0.81 | AURKA (0.62) | ITKAURKAAURKBKDRFGFR1 | |
| SCHEMBL10122949 | 0.80 | AURKA (0.59) | ITKAURKAAURKBKDRFGFR1 | |
| SCHEMBL10122947 | 0.80 | AURKA (0.61) | ITKAURKAAURKBKDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264422-A1 | METHOD OF TREATING DISEASE STATES USING SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS, INC. | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264422-A1 | METHOD OF TREATING DISEASE STATES USING SUBSTITUTED PYRAZOLE COMPOUNDS | AURKC, AURKA, AURKB | ITK 1059/4885AURKA 2/4885AURKB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.