Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 9/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.48 |
| ▸ | IGF1R | P08069 | 7/20 | 0.48 |
| ▸ | AURKA | O14965 | 8/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675351 | 0.86 | ITK (0.49) | ITKKDRFGFR1IGF1RAURKA | |
| SCHEMBL13675332 | 0.84 | ITK (0.62) | ITKKDRFGFR1IGF1RAURKA | |
| SCHEMBL18154707 | 0.79 | ITK (0.65) | ITKKDRFGFR1IGF1RAURKA | |
| SCHEMBL30230471 | 0.79 | ITK (0.65) | ITKKDRFGFR1IGF1RAURKA | |
| SCHEMBL29537888 | 0.77 | ITK (0.62) | ITKKDRFGFR1IGF1RAURKA | |
| SCHEMBL2120764 | 0.77 | ITK (0.62) | ITKKDRFGFR1IGF1RAURKA | |
| SCHEMBL18154778 | 0.74 | ITK (0.59) | ITKKDRFGFR1IGF1RAURKA | |
| SCHEMBL18297005 | 0.73 | ITK (0.58) | ITKKDRFGFR1IGF1RAURKA | |
| SCHEMBL802275 | 0.72 | ITK (1.00) | ITKKDRFGFR1IGF1RAURKA | |
| SCHEMBL18154760 | 0.72 | ITK (0.56) | ITKKDRFGFR1IGF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264422-A1 | METHOD OF TREATING DISEASE STATES USING SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS, INC. | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264422-A1 | METHOD OF TREATING DISEASE STATES USING SUBSTITUTED PYRAZOLE COMPOUNDS | AURKC, AURKA, AURKB | ITK 1059/4885KDR 2717/4885FGFR1 1382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.