Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.54 |
| ▸ | JAK1 | P23458 | 8/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.33 |
| ▸ | PAK4 | O96013 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | LTK | P29376 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13678309 | 0.86 | JAK2 (0.49) | JAK2JAK1CREBBPRPS6KB1JAK3 | |
| SCHEMBL10315608 | 0.81 | JAK2 (0.61) | JAK2JAK1JAK3DAPK3PAK4 | |
| SCHEMBL102811 | 0.80 | JAK2 (0.53) | JAK2JAK1JAK3DAPK3PAK4 | |
| SCHEMBL13541202 | 0.76 | JAK2 (0.60) | JAK2JAK1JAK3DAPK3PAK4 | |
| SCHEMBL19062191 | 0.76 | CREBBP (0.40) | JAK2JAK1CREBBPRPS6KB1JAK3 | |
| SCHEMBL13540942 | 0.74 | JAK2 (0.60) | JAK2JAK1JAK3DAPK3PAK4 | |
| SCHEMBL19790052 | 0.74 | JAK2 (0.70) | JAK2JAK1JAK3DAPK3PAK4 | |
| SCHEMBL13678279 | 0.74 | JAK2 (0.70) | JAK2JAK1JAK3DAPK3PAK4 | |
| Trifluoroacetic Acid SCHEMBL100597 | 0.73 | TYRO3 (0.50) | JAK2JAK1JAK3DAPK3PAK4 | |
| Trifluoroacetic Acid SCHEMBL29540688 | 0.73 | TYRO3 (0.50) | JAK2JAK1JAK3DAPK3PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598257-B2 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORPORATION (US) | 2009-10-06 | — | — | US | disclosed |
| US-20070135461-A1 | 3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile; immune-related diseases, skin disorders, myeloid proliferative disorders, cancer | INCYTE CORPORATION | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135461-A1 | 3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile; immune-related diseases, skin disorders, myeloid proliferative disorders, cancer | JAK1, JAK3, MAP3K4 | JAK2 4/4885JAK1 1/4885CREBBP 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.