Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.40 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13749241 | 0.84 | MAPT (0.67) | MAPTPOLBSMN1; SMN2APEX1ALDH1A1 | |
| SCHEMBL7168591 | 0.84 | MAPT (0.67) | MAPTPOLBSMN1; SMN2APEX1ALDH1A1 | |
| SCHEMBL9818964 | 0.84 | MAPT (0.67) | MAPTPOLBSMN1; SMN2APEX1ALDH1A1 | |
| SCHEMBL2326248 | 0.82 | MAPT (0.64) | MAPTPOLBSMN1; SMN2APEX1ALDH1A1 | |
| SCHEMBL13720687 | 0.82 | MAPT (0.64) | MAPTPOLBSMN1; SMN2APEX1ALDH1A1 | |
| SCHEMBL14071618 | 0.81 | MAPT (0.63) | MAPTPOLBSMN1; SMN2APEX1ALDH1A1 | |
| SCHEMBL12568260 | 0.81 | APEX1 (0.75) | MAPTPOLBSMN1; SMN2APEX1ALDH1A1 | |
| SCHEMBL1020458 | 0.79 | MAPT (0.61) | MAPTPOLBSMN1; SMN2APEX1ALDH1A1 | |
| SCHEMBL4008254 | 0.78 | MAPT (0.60) | MAPTPOLBSMN1; SMN2APEX1ALDH1A1 | |
| SCHEMBL1471963 | 0.78 | MAPT (0.60) | MAPTPOLBSMN1; SMN2APEX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601841-B2 | Quinolinyl and benzothiazolyl modulators | AMGEN INC. (US) | 2009-10-13 | — | — | US | disclosed |