Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | COMT | P21964 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679552 | 0.93 | MAPT (0.69) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL14615282 | 0.92 | MAPT (0.68) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL15424127 | 0.91 | MAPT (0.68) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL1268279 | 0.90 | MAPT (0.85) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL2157955 | 0.90 | MAPT (0.65) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL14642415 | 0.88 | MAPT (0.65) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL20145731 | 0.88 | MAPT (0.63) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL15424132 | 0.88 | MAPT (0.58) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL13679580 | 0.87 | MAPT (0.67) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL15424119 | 0.85 | MAPT (0.59) | MAPTMEN1HTTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708299-B2 | Hedgehog antagonists having zinc binding moieties | GENENTECH, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |