Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14615282 | 0.89 | MAPT (0.68) | MAPTDGAT1MEN1KMT2AHTT | |
| SCHEMBL13679575 | 0.88 | MAPT (0.73) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL13679552 | 0.87 | MAPT (0.69) | MAPTMEN1KMT2AHTTKDM4E | |
| SCHEMBL1268279 | 0.86 | MAPT (0.85) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL15424127 | 0.85 | MAPT (0.68) | MAPTDGAT1MEN1KMT2AHTT | |
| SCHEMBL2291466 | 0.84 | MAPT (0.65) | MAPTDGAT1MEN1KMT2AHTT | |
| SCHEMBL29526041 | 0.84 | MAPT (0.65) | MAPTDGAT1MEN1KMT2AHTT | |
| SCHEMBL2157955 | 0.84 | MAPT (0.65) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL13679580 | 0.84 | MAPT (0.67) | MAPTMEN1KMT2AHTTKDM4E | |
| SCHEMBL13679539 | 0.84 | MAPT (0.67) | MAPTMEN1KMT2AHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |