Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
| ▸ | HTT | P42858 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14642417 | 0.87 | MEN1 (0.56) | MEN1HTTKMT2AMAPTCSF1R | |
| SCHEMBL15424141 | 0.86 | MAPT (0.60) | MEN1HTTKMT2AMAPTCSF1R | |
| SCHEMBL12480897 | 0.86 | MAPT (0.60) | MEN1HTTKMT2AMAPTCSF1R | |
| SCHEMBL13679714 | 0.86 | MEN1 (0.85) | MEN1HTTKMT2AMAPTNPC1 | |
| SCHEMBL14642412 | 0.86 | MEN1 (1.00) | MEN1HTTKMT2AMAPTNPC1 | |
| SCHEMBL15424145 | 0.85 | MEN1 (0.53) | MEN1HTTKMT2AMAPTTP53 | |
| SCHEMBL14642491 | 0.85 | MEN1 (0.77) | MEN1HTTKMT2AMAPTNPC1 | |
| SCHEMBL14642445 | 0.84 | MEN1 (0.75) | MEN1HTTKMT2AMAPTNPC1 | |
| SCHEMBL2157955 | 0.83 | MAPT (0.65) | MEN1HTTKMT2AMAPTTP53 | |
| SCHEMBL12481925 | 0.83 | MAPT (0.65) | MEN1HTTKMT2AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |