Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679714 | 0.92 | MEN1 (0.85) | MEN1HTTKMT2AMAPTKDM4E | |
| SCHEMBL14642442 | 0.89 | MEN1 (0.79) | MEN1HTTKMT2AMAPTKDM4E | |
| SCHEMBL13679559 | 0.88 | MEN1 (0.78) | MEN1HTTKMT2AMAPTALDH1A1 | |
| SCHEMBL14642491 | 0.87 | MEN1 (0.77) | MEN1HTTKMT2AMAPTKDM4E | |
| SCHEMBL14642445 | 0.86 | MEN1 (0.75) | MEN1HTTKMT2AMAPTKDM4E | |
| SCHEMBL13679623 | 0.86 | MEN1 (0.75) | MEN1HTTKMT2AMAPTKDM4E | |
| SCHEMBL15557427 | 0.86 | MEN1 (0.75) | MEN1HTTKMT2AMAPTKDM4E | |
| SCHEMBL13679611 | 0.85 | MEN1 (0.74) | MEN1HTTKMT2AMAPTKDM4E | |
| SCHEMBL15424138 | 0.84 | MAPT (0.75) | MEN1HTTKMT2AMAPTKDM4E | |
| SCHEMBL15424140 | 0.84 | MEN1 (0.73) | MEN1HTTKMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |