Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | KIF5B | P33176 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 17/20 | 0.52 |
| ▸ | BRAF | P15056 | 17/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19916608 | 0.91 | RAF1 (0.60) | RETKIF5BKDREGFRLCK | |
| SCHEMBL19258530 | 0.91 | RAF1 (0.60) | RETKIF5BKDREGFRLCK | |
| SCHEMBL13680228 | 0.90 | BRAF (0.62) | RETKIF5BKDREGFRLCK | |
| SCHEMBL16692921 | 0.90 | BRAF (0.54) | RETKIF5BKDREGFRLCK | |
| SCHEMBL16692928 | 0.87 | BRAF (0.56) | RETKIF5BKDREGFRLCK | |
| SCHEMBL13680227 | 0.86 | BRAF (0.64) | RETKIF5BKDREGFRLCK | |
| SCHEMBL16692912 | 0.85 | KDM1A (0.66) | KDREGFRRAF1BRAF | |
| SCHEMBL1013319 | 0.83 | KDM1A (0.67) | RETKIF5BKDREGFRLCK | |
| SCHEMBL1012180 | 0.83 | KDR (0.73) | RETKIF5BKDREGFRLCK | |
| SCHEMBL1011934 | 0.82 | EGFR (0.64) | RETKIF5BKDREGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |