Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 10/20 | 0.60 |
| ▸ | BRAF | P15056 | 10/20 | 0.60 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | KIF5B | P33176 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.51 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19916608 | 0.93 | RAF1 (0.60) | RAF1BRAFKDREGFRRET | |
| SCHEMBL13680209 | 0.91 | RET (0.52) | RAF1BRAFKDREGFRRET | |
| SCHEMBL13680228 | 0.91 | BRAF (0.62) | RAF1BRAFKDREGFRRET | |
| SCHEMBL16692921 | 0.91 | BRAF (0.54) | RAF1BRAFKDREGFRRET | |
| SCHEMBL16692928 | 0.89 | BRAF (0.56) | RAF1BRAFKDREGFRRET | |
| SCHEMBL13680227 | 0.88 | BRAF (0.64) | RAF1BRAFKDREGFRRET | |
| SCHEMBL16692912 | 0.87 | KDM1A (0.66) | RAF1BRAFKDREGFR | |
| SCHEMBL17278105 | 0.87 | RAF1 (0.68) | RAF1BRAF | |
| SCHEMBL1013319 | 0.85 | KDM1A (0.67) | RAF1BRAFKDREGFRRET | |
| SCHEMBL1012180 | 0.84 | KDR (0.73) | RAF1BRAFKDREGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |