Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680516 | 0.81 | CYP1A2 (0.39) | MAPTCYP2A6NPC1RAB9AGSK3B | |
| SCHEMBL13680518 | 0.79 | MAPT (0.41) | MAPTNPC1RAB9APIK3CAGSK3B | |
| SCHEMBL13680469 | 0.78 | NPC1 (0.42) | MAPTNPC1RAB9APIK3CATDO2 | |
| SCHEMBL31174412 | 0.77 | CYP2A6 (0.68) | CYP2A6MKNK1MKNK2CA1CA2 | |
| SCHEMBL3754419 | 0.77 | CYP2A6 (0.68) | CYP2A6MKNK1MKNK2CA1CA2 | |
| SCHEMBL13680455 | 0.75 | CYP2A6 (0.45) | MAPTCYP2A6NPC1RAB9AGSK3B | |
| SCHEMBL15935065 | 0.75 | MAPT (0.51) | MAPTNPC1RAB9AGSK3BMEN1 | |
| SCHEMBL31288170 | 0.75 | HDAC6 (0.45) | CYP2A6MKNK1MKNK2CA1CA2 | |
| SCHEMBL13680715 | 0.74 | TDP1 (0.42) | MAPTNPC1RAB9AL3MBTL1GSK3B | |
| SCHEMBL13680506 | 0.73 | MAPK1 (0.51) | MAPTL3MBTL1GSK3BMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |