Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680568 | 0.83 | P4HTM (0.44) | MAPK1GSK3BKDM4EALDH1A1LMNA | |
| SCHEMBL20339324 | 0.82 | ALDH1A1 (0.51) | MAPK1DYRK1AKDM4EHPGDALDH1A1 | |
| SCHEMBL20339971 | 0.78 | MAPK1 (0.43) | MAPK1DYRK1AKDM4EHPGDALDH1A1 | |
| SCHEMBL13680898 | 0.77 | MAPK1 (0.43) | MAPK1DYRK1AKDM4EHPGDALDH1A1 | |
| SCHEMBL27176217 | 0.77 | AXL (0.58) | MAPK1DYRK1AKDM4EHPGDALDH1A1 | |
| SCHEMBL5655892 | 0.76 | GSK3B (0.64) | GSK3BKDM4EHPGDALDH1A1POLB | |
| SCHEMBL29248979 | 0.75 | ALOX15 (0.56) | MAPK1KDM4EHPGDALDH1A1LMNA | |
| SCHEMBL13680716 | 0.73 | MAPT (0.39) | MAPK1GSK3BKDM4EHPGDPLIN1 | |
| SCHEMBL2037294 | 0.73 | MAPK1 (0.59) | MAPK1DYRK1AKDM4EHPGDL3MBTL1 | |
| SCHEMBL11041168 | 0.73 | MAPK1 (0.59) | MAPK1DYRK1AKDM4ETDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |