Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680486 | 0.85 | MAPT (0.52) | MEN1ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL30175854 | 0.83 | CYP17A1 (0.54) | PSMB8CA12CA1CA9PRKDC | |
| SCHEMBL4903830 | 0.83 | CYP17A1 (0.54) | PSMB8CA12CA1CA9PRKDC | |
| SCHEMBL2030467 | 0.83 | CYP17A1 (0.54) | PSMB8CA12CA1CA9PRKDC | |
| SCHEMBL29957607 | 0.82 | PSMB8 (0.51) | PSMB8CA12CA1CA9PRKDC | |
| SCHEMBL14923530 | 0.82 | CA12 (0.46) | PSMB8CA12CA1CA9PRKDC | |
| SCHEMBL20865536 | 0.81 | CYP17A1 (0.68) | PSMB8CA12CA1CA9PRKDC | |
| SCHEMBL6816610 | 0.80 | KLK7 (0.71) | PSMB8CA12CA1CA9CYP17A1 | |
| SCHEMBL13680609 | 0.80 | HDAC1 (0.47) | CA1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL13055402 | 0.79 | CYP17A1 (0.59) | PSMB8CA12CA1CA9CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |