Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.53 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680628 | 0.90 | CRBN (0.48) | PDE3BPDE3AGRIA1CACNG8MAPT | |
| SCHEMBL16090353 | 0.82 | MEN1 (0.59) | PDE3BPDE3AGRIA1CACNG8MAPT | |
| SCHEMBL1559008 | 0.78 | MAPT (0.79) | PDE3BPDE3AGRIA1CACNG8MAPT | |
| SCHEMBL8480061 | 0.78 | PDE3B (0.68) | PDE3BPDE3AMAPTNPC1MMP12 | |
| SCHEMBL13028342 | 0.78 | MAPT (0.54) | PDE3BPDE3AGRIA1CACNG8MAPT | |
| SCHEMBL15682666 | 0.78 | MAPT (0.55) | PDE3BPDE3AGRIA1CACNG8MAPT | |
| SCHEMBL13681010 | 0.78 | PDE3B (0.50) | PDE3BPDE3AGRIA1CACNG8MAPT | |
| SCHEMBL15668432 | 0.78 | ALDH1A1 (0.51) | PDE3BPDE3AMAPTNPC1MMP12 | |
| Hydrochloric Acid SCHEMBL5771609 | 0.77 | MAPT (0.77) | PDE3BPDE3AGRIA1CACNG8MAPT | |
| SCHEMBL16090359 | 0.77 | MAPT (0.53) | PDE3BPDE3AGRIA1CACNG8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |