Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.64 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18483006 | 0.83 | BRD4 (0.51) | BRD4CREBBPBMPR1BBMPR1AACVRL1 | |
| SCHEMBL19280560 | 0.81 | BRD4 (0.62) | BRD4HRH3CREBBPPGRALDH1A1 | |
| SCHEMBL16573986 | 0.79 | BRD4 (0.50) | BRD4HRH3CREBBPBMPR1BBMPR1A | |
| SCHEMBL9919107 | 0.79 | BRD4 (0.59) | BRD4CREBBPALDH1A1 | |
| SCHEMBL18656033 | 0.76 | PIK3CD (0.43) | FYNCLK4DYRK1BPGRALDH1A1 | |
| SCHEMBL20506937 | 0.76 | BRD4 (0.58) | BRD4 | |
| SCHEMBL18518471 | 0.75 | ALDH1A1 (0.50) | BRD4CREBBPALDH1A1BMPR1BBMPR1A | |
| SCHEMBL13680660 | 0.75 | GRIN2B (0.43) | — | |
| SCHEMBL19931110 | 0.74 | BRD4 (0.64) | BRD4SOS1HRH3CREBBPBMPR1B | |
| SCHEMBL18471235 | 0.74 | BRD4 (0.50) | BRD4CREBBPBMPR1BBMPR1AACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |