Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6754322 | 0.87 | KDM4E (0.57) | KDM4EALDH1A1GLAGAACCR1 | |
| SCHEMBL14606354 | 0.76 | CCR1 (0.62) | KDM4ECYP2A6LMNAMAPTALDH1A1 | |
| SCHEMBL13992608 | 0.75 | CYP3A4 (0.49) | KDM4ECYP2A6LMNAMAPTALDH1A1 | |
| SCHEMBL1356959 | 0.75 | LMNA (0.70) | KDM4ECYP2A6LMNAMAPTALDH1A1 | |
| SCHEMBL9374034 | 0.75 | KDM4E (0.73) | KDM4ECYP2A6LMNAMAPTALDH1A1 | |
| SCHEMBL1575023 | 0.74 | LMNA (0.59) | KDM4ECYP2A6LMNAMAPTALDH1A1 | |
| SCHEMBL8575623 | 0.73 | LMNA (0.68) | KDM4ECYP2A6LMNAMAPTALDH1A1 | |
| SCHEMBL12569052 | 0.73 | LMNA (0.68) | KDM4ECYP2A6LMNAMAPTALDH1A1 | |
| SCHEMBL13136597 | 0.73 | JAK2 (0.44) | KDM4ECYP2A6LMNAMAPTALDH1A1 | |
| SCHEMBL13136589 | 0.73 | HDAC1 (0.50) | KDM4ECYP2A6LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |