Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 8/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3508328 | 0.82 | DYRK1A (0.52) | ADORA2AADORA1DYRK1ABRD4GSK3B | |
| SCHEMBL13680689 | 0.78 | CYP2A6 (0.49) | ADORA2AADORA1CCR1CCR8CYP2A6 | |
| SCHEMBL31704587 | 0.76 | DYRK1A (0.47) | ADORA2AADORA1DYRK1ABRD4GSK3B | |
| SCHEMBL31705904 | 0.76 | DYRK1A (0.47) | ADORA2AADORA1DYRK1ABRD4GSK3B | |
| SCHEMBL3422361 | 0.75 | CCR1 (0.75) | CCR1CCR8CYP2A6TGFBR1MAPK14 | |
| SCHEMBL31704631 | 0.75 | DYRK1A (0.46) | ADORA2AADORA1DYRK1ABRD4CREBBP | |
| SCHEMBL31706865 | 0.75 | DYRK1A (0.46) | ADORA2AADORA1DYRK1ABRD4CREBBP | |
| SCHEMBL21475947 | 0.75 | DYRK1A (0.55) | ADORA2AADORA1DYRK1ACCR1CCR8 | |
| SCHEMBL21241085 | 0.74 | CCR1 (0.54) | CCR1CCR8CYP2A6TGFBR1MAPK14 | |
| SCHEMBL2614970 | 0.70 | CCR1 (0.65) | CCR1CCR8CYP2A6TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |