Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 9/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | SORD | Q00796 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4546569 | 0.84 | KDM4E (0.50) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL21346283 | 0.81 | KDM4E (0.47) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL8345923 | 0.81 | MAPT (0.47) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL7458233 | 0.81 | MAPT (0.47) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL2971911 | 0.78 | MAPT (0.48) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL20072401 | 0.78 | MAPT (0.44) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL2976861 | 0.77 | MAPT (0.47) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL8119056 | 0.72 | MMP9 (0.43) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL24983709 | 0.70 | MAPT (0.41) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL12755493 | 0.70 | MMP9 (0.41) | KDM4EMAPTALDH1A1HSD17B10MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |