Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.60 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28193174 | 0.94 | — | — | |
| Bicarbonate SCHEMBL5826092 | 0.94 | CA4 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL28582066 | 0.94 | CA4 (0.67) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL1331273 | 0.94 | — | — | |
| Bicarbonate SCHEMBL29061109 | 0.94 | CA4 (0.67) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL7518275 | 0.94 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL25 | 0.94 | — | — | |
| Bicarbonate SCHEMBL10408290 | 0.94 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL20604683 | 0.94 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL1331459 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110228815-B | Method for producing compound zinc carbonate sodium salt from phenol wastewater containing zinc salt | 山西大学 | 2021-05-14 | — | — | CN | claimed |
| WO-2011146611-A1 | MODIFIED GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR AMINE DRUGS | ABON PHARMACEUTICALS, LLC (US) | 2011-11-24 | — | — | WO | claimed |
| US-20110287096-A1 | MODIFIED GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR AMINE DRUGS | ABON PHARMACEUTICALS, LLC (US) | 2011-11-24 | — | — | US | claimed |
| CN-110228815-B | Method for producing compound zinc carbonate sodium salt from phenol wastewater containing zinc salt | 山西大学 | 2021-05-14 | — | — | CN | disclosed |
| US-10722833-B2 | Purification process | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2020-07-28 | — | — | US | disclosed |
| CN-110228815-A | A method of phenolic waste water containing zinc salt produces compound zinc carbonate sodium salt | 山西大学 | 2019-09-13 | — | — | CN | disclosed |
| US-10252211-B2 | Purification process | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2019-04-09 | — | — | US | disclosed |
| US-20190009206-A1 | Purification Process | JOHNSON MATTHEY DAVY TECHNOLOGIES LIMITED (GB) | 2019-01-10 | — | — | US | disclosed |
| EP-2760558-B1 | PURIFICATION PROCESS | JOHNSON MATTHEY PLC (GB) | 2018-02-21 | — | — | EP | disclosed |
| US-20140296607-A1 | PURIFICATION PROCESS | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2014-10-02 | — | — | US | disclosed |
| EP-2760558-A1 | PURIFICATION PROCESS | Johnson Matthey Public Limited Company (GB) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013045883-A1 | PURIFICATION PROCESS | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2013-04-04 | — | — | WO | disclosed |
| US-6558641-B1 | Such as calcined alumina trihydrate, basic zinc carbonate, sodium carbonate and clay binder; removing hydrogen chloride and/or chlorine containing organic compounds from gas streams | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 2003-05-06 | — | — | US | disclosed |
| EP-1051246-B1 | ABSORBENTS | ICI PLC (GB) | 2002-04-24 | — | — | EP | disclosed |
| EP-1051246-A1 | ABSORBENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999039819-A1 | ABSORBENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1999-08-12 | — | — | WO | disclosed |
| US-5573699-A | SODIUM ZINC CARBONATE HYDRATE COMPLEX SALT DEODORANT | CHURCH & DWIGHT CO., INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-4112330-A | BOROSILICATE GLASS, BARIUM BORATE GLASS, ANTIMONY, SILICON | GENERAL MOTORS CORPORATION (US) | 1978-09-05 | — | — | US | disclosed |