Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14043732 | 0.80 | L3MBTL1 (0.37) | MKNK1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL13683112 | 0.69 | HPGD (0.39) | MKNK1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL13184402 | 0.66 | GAA (0.36) | — | |
| SCHEMBL5526593 | 0.65 | PARP1 (0.42) | — | |
| SCHEMBL5315676 | 0.65 | L3MBTL1 (0.37) | MKNK1CHRM2L3MBTL1TAAR1 | |
| SCHEMBL16200361 | 0.65 | L3MBTL1 (0.37) | MKNK1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL16600472 | 0.65 | CREBBP (0.45) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL5334794 | 0.65 | L3MBTL1 (0.43) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL13184412 | 0.64 | — | — | |
| SCHEMBL12152251 | 0.62 | ADORA2A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |